{"id":5483,"date":"2022-09-07T15:00:39","date_gmt":"2022-09-07T06:00:39","guid":{"rendered":"https:\/\/www.imass.nagoya-u.ac.jp\/?p=5483"},"modified":"2022-09-21T11:24:43","modified_gmt":"2022-09-21T02:24:43","slug":"20220907_tagawa","status":"publish","type":"post","link":"https:\/\/www.imass.nagoya-u.ac.jp\/en\/research\/20220907_tagawa.html","title":{"rendered":"\u6df7\u305c\u308b\u3060\u3051\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u5b50\u3092\u5c01\u5165\u53ef\u80fd\u306aDNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u306e\u4f5c\u88fd\u306b\u6210\u529f\uff01\uff0d\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\u30b7\u30b9\u30c6\u30e0\u306e\u30ad\u30e3\u30ea\u30a2\u306a\u3069\u3078\u306e\u5fdc\u7528\u306b\u671f\u5f85\uff0d"},"content":{"rendered":"<p style=\"text-align: center;\"><a href=\"https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa01.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa01.jpg\" alt=\"\" width=\"1920\" height=\"879\" class=\"alignnone size-full wp-image-5482\" srcset=\"https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa01.jpg 1920w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa01-300x137.jpg 300w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa01-1024x469.jpg 1024w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa01-768x352.jpg 768w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa01-1536x703.jpg 1536w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/><\/a><\/p>\r\n<p><span style=\"font-size: 16px;\"><strong><span style=\"font-size: 20px;\">\u3010\u672c\u7814\u7a76\u306e\u30dd\u30a4\u30f3\u30c8\u3011<\/span><\/strong><\/span><\/p>\r\n<div style=\"padding: 30px; margin-bottom: 30px; border: 1px solid #33c6cc; border-radius: 10px; background-color: #ffffff;\">\r\n<ul style=\"list-style-type: disc;\">\r\n<li><strong><span style=\"font-size: 20px;\">DNA\u3092\u4ecb\u3057\u3066\u7c92\u5b50\u9593\u8ddd\u96e2\u3092\u5236\u5fa1\u3057\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u9175\u7d20\u306a\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u5b50\u3092\u5c01\u5165\u53ef\u80fd\u306aDNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u306e\u4f5c\u88fd\u306b\u6210\u529f\u3057\u305f\u3002<\/span><\/strong><\/li>\r\n<li><strong><span style=\"font-size: 20px;\">\u7d50\u6676\u306b\u30d3\u30aa\u30c1\u30f3<span style=\"color: #800000;\"><sup>\u6ce81\uff09<\/sup><\/span>\u5206\u5b50\u3084\u9175\u7d20\u304c\u7d50\u5408\u3059\u308b\u305f\u3081\u306eDNA\u3092\u7d44\u307f\u8fbc\u3080\u3053\u3068\u3067\u3001\u7c21\u4fbf\u304b\u3064\u8fc5\u901f\u306a\u7d50\u6676\u5185\u3078\u306e\u6a19\u7684\u5206\u5b50\u306e\u4fdd\u6301\u3092\u5b9f\u73fe\u3057\u305f\u3002<\/span><\/strong><\/li>\r\n<li><strong><span style=\"font-size: 20px;\">\u30b2\u30ce\u30e0\u7de8\u96c6\u9175\u7d20\u3092\u62c5\u6301\u3057\u305f\u7d50\u6676\u3092\u30d1\u30fc\u30c6\u30a3\u30af\u30eb\u30ac\u30f3\u6cd5\u306b\u3088\u308a\u690d\u7269\u7d30\u80de\u306b\u6253\u3061\u8fbc\u307f\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u304c\u884c\u308f\u308c\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u305f\u3002<\/span><\/strong><\/li>\r\n<li><strong><span style=\"font-size: 20px;\">\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\u30b7\u30b9\u30c6\u30e0\u306e\u30ad\u30e3\u30ea\u30a2<span style=\"color: #800000;\"><sup>\u6ce82\uff09<\/sup><\/span>\u3084\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc\u3001\u65b0\u898f\u6750\u6599\u5275\u88fd\u306a\u3069\u3078\u306e\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/span><\/strong><\/li>\r\n<\/ul>\r\n<\/div>\r\n<p>&nbsp;<\/p>\r\n<p><span style=\"font-size: 16px;\"><strong><span style=\"font-size: 20px;\"> \u3010\u6982\u8981\u3011<\/span><br><\/strong><\/span><\/p>\r\n<hr \/>\r\n<p><span style=\"font-size: 16px;\"><br><span style=\"font-size: 20px;\">\u3000\u56fd\u7acb\u5927\u5b66\u6cd5\u4eba\u6771\u6d77\u56fd\u7acb\u5927\u5b66\u6a5f\u69cb \u540d\u53e4\u5c4b\u5927\u5b66\u672a\u6765\u6750\u6599\u30fb\u30b7\u30b9\u30c6\u30e0\u7814\u7a76\u6240\u306e\u7530\u5ddd \u7f8e\u7a42 \u51c6\u6559\u6388\u3001\u6a2a\u68ee \u771f\u9ebb \u7279\u4efb\u52a9\u6559\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240 \u751f\u7269\u30d7\u30ed\u30bb\u30b9\u90e8\u9580\u306e\u83c5\u91ce \u8302\u592b \u4e3b\u4efb\u7814\u7a76\u54e1\u3001\u9234\u6728 \u96bc\u4eba \u7523\u7dcf\u7814\u7279\u5225\u7814\u7a76\u54e1\u3001\u4e2d\u6751 \u5f70\u826f \u7814\u7a76\u54e1\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001<span style=\"text-decoration: underline;\">\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u306e\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb\u30b5\u30a4\u30ba\u306e\u5206\u5b50\u3092\u7c21\u4fbf\u3001\u8fc5\u901f\u306b\u5c01\u5165\u53ef\u80fd\u306aDNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u306e\u958b\u767a\u306b\u6210\u529f<\/span>\u3057\u307e\u3057\u305f\u3002<br>\u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u8868\u9762\u306bDNA\u3092\u4fee\u98fe\u3059\u308b\u3053\u3068\u3067\u3001DNA\u306e\u30d7\u30ed\u30b0\u30e9\u30de\u30d6\u30eb\u306a\u6027\u8cea\u3092\u5229\u7528\u3057\u3066\u7c92\u5b50\u9593\u8ddd\u96e2\u3084\u7a7a\u9593\u914d\u7f6e\u3092\u5236\u5fa1\u3057\u3001\u7d50\u6676\u5185\u306e\u7d30\u5b54\u306b\u30b2\u30ce\u30e0\u7de8\u96c6\u9175\u7d20CRISPR-Cas9<strong><span style=\"color: #800000;\"><sup>\u6ce83\uff09<\/sup><\/span><\/strong>\u7b49\u3092\u5c01\u5165\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<br>\u3000DNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u306f\u5c40\u5728\u8868\u9762\u30d7\u30e9\u30ba\u30e2\u30f3\u5171\u9cf4<strong><span style=\"color: #800000;\"><sup>\u6ce84\uff09<\/sup><\/span><\/strong> 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underline;\">\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\u30b7\u30b9\u30c6\u30e0\u306e\u30ad\u30e3\u30ea\u30a2\u3084\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc\u3001\u65b0\u898f\u6750\u6599\u5275\u88fd\u306a\u3069\u3078\u306e\u5fdc\u7528\u304c\u671f\u5f85<\/span>\u3055\u308c\u307e\u3059\u3002<br>\u3000\u672c\u7814\u7a76\u6210\u679c\u306f\u30012022\u5e749\u67086\u65e5\u4ed8\u30a4\u30ae\u30ea\u30b9\u79d1\u5b66\u96d1\u8a8c\u300cSoft Matter\u300d\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<p><span style=\"font-size: 16px;\"><strong>[\u7814\u7a76\u80cc\u666f\u3068\u5185\u5bb9]<br><\/strong><\/span><\/p>\r\n<hr \/>\r\n<p><span style=\"font-size: 16px;\">\u00a0<br>\u3000\u9175\u7d20\u3084\u6297\u4f53\u3068\u3044\u3063\u305f\u533b\u5b66\u30fb\u751f\u7269\u5b66\u306e\u5206\u91ce\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u9ad8\u5206\u5b50\u3092\u3001\u4fdd\u8b77\u3001\u8caf\u8535\u3001\u305d\u3057\u3066\u7d30\u80de\u3078\u8f38\u9001\u3059\u308b\u76ee\u7684\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306b\u3001\u3055\u307e\u3056\u307e\u306a\u65b0\u898f\u6a5f\u80fd\u6027\u6750\u6599\u306e\u958b\u767a\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u3082\u3001DNA\u306f\u9078\u629e\u7684\u8a8d\u8b58\u30fb\u7d50\u5408\u80fd\u529b\u306b\u512a\u308c\u305f\u751f\u4f53\u7269\u8cea\u3067\u3042\u308a\u3001\u8fd1\u5e74DNA\u69cb\u9020\u4f53\u306b\u9175\u7d20\u3092\u5c01\u5165\u3059\u308b\u3053\u3068\u3067\u6d3b\u6027\u3084\u5b89\u5b9a\u6027\u306e\u5411\u4e0a\u304c\u5831\u544a\u3055\u308c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002DNA\u69cb\u9020\u4f53\u306f\u3001DNA\u306e\u307f\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u306b\u3001\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\u306e\u30ad\u30e3\u30ea\u30a2\u3068\u3057\u3066\u306f\u525b\u6027\u3084\u5b89\u5b9a\u6027\u304c\u5341\u5206\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u79c1\u305f\u3061\u306f\u3001DNA\u306b\u300c\u30ca\u30ce\u7c92\u5b50\u300d\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u69cb\u9020\u306b\u7740\u76ee\u3057\u307e\u3057\u305f\u3002<br>\u3000\u300c\u30ca\u30ce\u7c92\u5b50\u300d\u306f\u3001\u305d\u308c\u81ea\u8eab\u3067\u306f\u79e9\u5e8f\u7684\u306b\u914d\u5217\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u304c\u3001\u300c\u30ca\u30ce\u7c92\u5b50\u300d\u306e\u8868\u9762\u306b\u5869\u57fa\u914d\u5217\u8a2d\u8a08\u3092\u3057\u305f\u5408\u6210DNA\u3092\u4fee\u98fe\u3059\u308b\u3068\u3001\u7c92\u5b50\u9593\u8ddd\u96e2\u3084\u7a7a\u9593\u914d\u7f6e\u3092\u5236\u5fa1\u3057\u3001\u7c92\u5b50\u5145\u586b\u7387<strong><span style=\"color: #800000;\"><sup>\u6ce85\uff09<\/sup><\/span><\/strong> \u306e\u4f4e\u3044\u7d50\u6676\u69cb\u9020\u3092\u4f5c\u88fd\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306eDNA\u4fee\u98fe\u30ca\u30ce\u7c92\u5b50\u306b\u3088\u3063\u3066\u69cb\u6210\u3055\u308c\u305f\u7d50\u6676\u201cDNA\u4fee\u98fe\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u201d\u306f\u3001\u7a7a\u5b54\u3092\u591a\u6570\u3082\u3061\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u306e\u30ca\u30ce\u30b5\u30a4\u30ba\u306e\u5206\u5b50\u3092\u9ad8\u5bc6\u5ea6\u306b\u7d50\u5408\u30fb\u5c01\u5165\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002DNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u306fDNA\u3068\u91d1\u30ca\u30ce\u7c92\u5b50\u306e\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u6750\u6599\u3068\u306a\u308b\u305f\u3081\u3001DNA\u69cb\u9020\u4f53\u3068\u6bd4\u3079\u3066\u525b\u6027\u30fb\u6a5f\u68b0\u7684\u5f37\u5ea6\u306e\u5411\u4e0a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u91d1\u30ca\u30ce\u7c92\u5b50\u306f\u3001\u7279\u7570\u7684\u306a\u5149\u5b66\u7684\u30fb\u78c1\u6c17\u7684\u7279\u6027\u3084\u89e6\u5a92\u4f5c\u7528\u3092\u6709\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u3055\u307e\u3056\u307e\u306a\u5fdc\u7528\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u3053\u308c\u307e\u3067DNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u306f\u3001\u4e3b\u306b\u300c\u30ca\u30ce\u7c92\u5b50\u300d\u306e\u914d\u7f6e\u5236\u5fa1\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u9ad8\u5206\u5b50\u3092\u5185\u90e8\u306b\u5c01\u5165\u3067\u304d\u308b\u304b\u306e\u691c\u8a0e\u306f\u884c\u308f\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br>\u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u7d50\u6676\u306e\u7a7a\u9593\u306b\u7740\u76ee\u3057\u3001\u30ca\u30ce\u30b5\u30a4\u30ba\u306e\u5206\u5b50\u3092\u88c5\u586b\u3059\u308b\u305f\u3081\u306eDNA\u4fee\u98fe\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u306e\u30c7\u30b6\u30a4\u30f3\u306b\u3064\u3044\u3066\u691c\u8a0e\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u7d50\u6676\u306b\u5206\u5b50\u3092\u4fdd\u6301\u3059\u308b\u305f\u3081\u306e\u6a5f\u69cb\u3068\u3057\u3066\u3001\u751f\u7269\u5b66\u7684\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u3068\u3057\u3066\u3088\u304f\u5229\u7528\u3055\u308c\u308b\u30d3\u30aa\u30c1\u30f3\u2015\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\u76f8\u4e92\u4f5c\u7528\u306e\u5229\u7528\u3092\u8a66\u307f\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u30c4\u30fc\u30eb\u3068\u3057\u3066\u9700\u8981\u306e\u9ad8\u3044CRISPR\/Cas9\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\uff08RNP\uff09\u3092\u7528\u3044\u3066\u3001DNA\u7d50\u5408\u80fd\u3092\u4ecb\u3057\u305f\u5206\u5b50\u5c01\u5165\u306b\u3064\u3044\u3066\u3082\u691c\u8a0e\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/span><span style=\"font-size: 16px;\"><\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<div id=\"attachment_5511\" style=\"width: 1034px\"  class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa02.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa02-1024x665.png\" alt=\"\" width=\"1024\" height=\"665\" class=\"wp-image-5511 size-large\" srcset=\"https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa02-1024x665.png 1024w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa02-300x195.png 300w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa02-768x499.png 768w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa02.png 1408w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><p class=\"wp-caption-text\"><strong><span style=\"font-size: 14px;\">\u56f31. DNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u3078\u306e\u5206\u5b50\u5c01\u5165. (a)\u30b9\u30ad\u30fc\u30e0 (b)DNA\u30c7\u30b6\u30a4\u30f3 (c)\u5206\u5b50\u5c01\u5165\u8a55\u4fa1<\/span><\/strong><\/p><\/div>\r\n<p><span style=\"font-size: 16px;\">\u00a0<\/span><\/p>\r\n<p><span style=\"font-size: 16px;\">\u3000\u56f31\u306b\u3001\u4eca\u56de\u9054\u6210\u3057\u305fDNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u3078\u306e\u5206\u5b50\u5c01\u5165\u306e\u6982\u7565\u56f3\u3092\u793a\u3057\u307e\u3059\u3002DNA\uff08\u30ea\u30ac\u30f3\u30c9DNA\uff09\u3067\u88ab\u8986\u3055\u308c\u305f\u91d1\u30ca\u30ce\u7c92\u5b50\u3068\u30ca\u30ce\u7c92\u5b50\u540c\u58eb\u3092\u67b6\u6a4b\u3059\u308b\u305f\u3081\u306e\u30ea\u30f3\u30ab\u30fcDNA\u3092\u6df7\u5408\u3057\u3001\u52a0\u71b1\u30fb\u5f90\u51b7\u3059\u308b\u3053\u3068\u3067DNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u3092\u4f5c\u88fd\u3057\u307e\u3057\u305f\uff08\u56f31a\uff09\u3002\u30b9\u30da\u30fc\u30b5\u30fc\u914d\u5217\u306e\u9577\u3055\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u3001\u7c92\u5b50\u9593\u8ddd\u96e2\u3092\u4eba\u70ba\u7684\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u3066\u3001\u7a7a\u9699\u7387\u306e\u9ad8\u3044\u7d50\u6676\u3092\u4f5c\u88fd\u3057\u307e\u3057\u305f\uff08\u56f31b\uff09\u3002\u3053\u306e\u30b9\u30da\u30fc\u30b5\u30fc\u914d\u5217\u306b\u306f\u3001\u30d3\u30aa\u30c1\u30f3\u3092\u7d50\u5408\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u30d3\u30aa\u30c1\u30f3\u2010\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u3001\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\u5206\u5b50\u304c\u5185\u90e8\u306b\u3068\u3069\u307e\u308b\u3088\u3046\u306b\u8a2d\u8a08\u3057\u307e\u3057\u305f\u3002\u5f97\u3089\u308c\u305f\u7d50\u6676\u306b\u6a19\u7684\u3068\u3059\u308b\u5206\u5b50\u3092\u52a0\u3048\u3066\u5ba4\u6e29\u4e0b\u30671\u6642\u9593\u7a0b\u5ea6\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30b7\u30e7\u30f3\u3001\u53ca\u3073\u6355\u6349\u3055\u308c\u306a\u304b\u3063\u305f\u5206\u5b50\u3092\u6d17\u6d44\u9664\u53bb\u5f8c\u3001\u5171\u7126\u70b9\u30ec\u30fc\u30b6\u30fc\u9855\u5fae\u93e1<strong><span style=\"color: #800000;\"><sup>\u6ce86\uff09<\/sup><\/span><\/strong>\u3092\u7528\u3044\u3066\u7d50\u6676\u3078\u306e\u5206\u5b50\u306e\u5c01\u5165\u72b6\u614b\u3092\u4e09\u6b21\u5143\u7684\u306b\u89b3\u5bdf\u3057\u307e\u3057\u305f\uff08\u56f31c\uff09\u3002 <br><\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<div id=\"attachment_5523\" style=\"width: 1034px\"  class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa03.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa03-1024x924.png\" alt=\"\" width=\"1024\" height=\"924\" class=\"size-large wp-image-5523\" srcset=\"https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa03-1024x924.png 1024w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa03-300x271.png 300w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa03-768x693.png 768w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa03.png 1408w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><p class=\"wp-caption-text\"><strong><span style=\"font-size: 14px;\">\u56f32. \u30d3\u30aa\u30c1\u30f3\u5206\u5b50\u3067\u6a5f\u80fd\u5316\u3055\u308c\u305fDNA\u4fee\u98fe\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u3078\u306e\u86cd\u5149\u6a19\u8b58\u3057\u305f\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\u5206\u5b50\u5c01\u5165. (a)\u7d50\u6676\u306e\u8d70\u67fb\u578b\u96fb\u5b50\u9855\u5fae\u93e1\u50cf\u3001(b)\u5206\u5b50\u5c01\u5165\u524d\u53ca\u3073\u5f8c\u306eX\u7dda\u5c0f\u89d2\u6563\u4e71\u6e2c\u5b9a\u306e\u89e3\u6790\u7d50\u679c\u3001(c)\u7d50\u6676\u65ad\u9762\u306b\u304a\u3051\u308b\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\u7531\u6765\u306e\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3068\u30e9\u30a4\u30f3\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3001(d)\u975e\u30d3\u30aa\u30c1\u30f3\u4fee\u98fe\u7d50\u6676\u65ad\u9762\u306b\u304a\u3051\u308b\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\u53ca\u3073\u7d50\u6676\u7531\u6765\u306e\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3068\u30e9\u30a4\u30f3\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3002<\/span><\/strong><\/p><\/div>\r\n<p><span style=\"font-size: 16px;\">\u00a0<br>\u3000X\u7dda\u5c0f\u89d2\u6563\u4e71<strong><span style=\"color: #800000;\"><sup>\u6ce87\uff09<\/sup><\/span><\/strong>\u3068\u8d70\u67fb\u578b\u96fb\u5b50\u9855\u5fae\u93e1<strong><span style=\"color: #800000;\"><sup>\u6ce88\uff09<\/sup><\/span><\/strong>\u3092\u7528\u3044\u3066\u7d50\u6676\u69cb\u9020\u306e\u8a55\u4fa1\u53ca\u3073\u5f62\u72b6\u306e\u89b3\u5bdf\u3092\u884c\u3044\u3001\u30d3\u30aa\u30c1\u30f3\u5206\u5b50\u3092\u5c0e\u5165\u3057\u305fDNA\u9396\u3092\u7528\u3044\u3066\u3001\u30c7\u30b6\u30a4\u30f3\u3057\u305f\u901a\u308a\u306e\u4f53\u5fc3\u7acb\u65b9\u683c\u5b50\u69cb\u9020\u306e\u83f1\u5f62\u5341\u4e8c\u9762\u4f53\u7d50\u6676\u3092\u4f5c\u88fd\u51fa\u6765\u305f\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\uff08\u56f32a\u3001b\uff09\u3002\u3053\u306e\u30d3\u30aa\u30c1\u30f3\u5206\u5b50\u304c\u7d44\u307f\u8fbc\u307e\u308c\u305f\u7d50\u6676\u306b\u86cd\u5149\u4fee\u98fe\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\u5206\u5b50\u3092\u5916\u90e8\u3088\u308a\u6dfb\u52a0\u3057\u305f\u7d50\u679c\u3001\u7d50\u6676\u306e\u5185\u90e8\u304b\u3089\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\u7531\u6765\u306e\u86cd\u5149\u304c\u5f97\u3089\u308c\u3001\u6e29\u548c\u306a\u6761\u4ef6\u3067\u7c21\u4fbf\u306b\u5206\u5b50\u5c01\u5165\u304c\u53ef\u80fd\u306a\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\uff08\u56f32c\uff09\u3002\u4e00\u65b9\u3067\u3001\u30d3\u30aa\u30c1\u30f3\u5206\u5b50\u304c\u7d44\u307f\u8fbc\u307e\u308c\u3066\u3044\u306a\u3044\u7d50\u6676\uff08\u9855\u5fae\u93e1\u89b3\u5bdf\u306e\u305f\u3081\u306b\u7570\u306a\u308b\u6ce2\u9577\u306e\u86cd\u5149\u5206\u5b50\u3067\u4fee\u98fe\uff09\u306b\u3064\u3044\u3066\u540c\u69d8\u306e\u5b9f\u9a13\u3092\u884c\u3046\u3068\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\u7531\u6765\u306e\u86cd\u5149\u5f37\u5ea6\u306f\u691c\u51fa\u3055\u308c\u305a\u3001\u30d3\u30aa\u30c1\u30f3\u4fee\u98fe\u304c\u5206\u5b50\u5c01\u5165\u306b\u52b9\u679c\u7684\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08\u56f32d\uff09\u3002\u307e\u305f\u3001\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\u5206\u5b50\u5c01\u5165\u5f8c\u3082\u7d50\u6676\u6027\u3092\u4fdd\u3064\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u3082\u78ba\u8a8d\u3057\u307e\u3057\u305f\uff08\u56f32d\uff09\u3002<br><\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<div id=\"attachment_5526\" style=\"width: 894px\"  class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa04.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa04-884x1024.png\" alt=\"\" width=\"884\" height=\"1024\" class=\"size-large wp-image-5526\" srcset=\"https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa04-884x1024.png 884w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa04-259x300.png 259w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa04-768x890.png 768w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa04-1326x1536.png 1326w, https:\/\/www.imass.nagoya-u.ac.jp\/wp\/wp-content\/uploads\/2022\/09\/tagawa04.png 1408w\" sizes=\"auto, (max-width: 884px) 100vw, 884px\" \/><\/a><p class=\"wp-caption-text\"><strong><span style=\"font-size: 14px;\">\u56f33. CRISPR\/Cas9\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53(RNP)\u3092\u5c01\u5165\u3057\u305fDNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676 (a)\u7d50\u6676\u65ad\u9762\u306b\u304a\u3051\u308b\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u5b50\u3067\u6a19\u8b58\u3057\u305fRNP\u306e\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3068\u30e9\u30a4\u30f3\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3001 (b)RNP \u5c01\u5165\u7d50\u6676\u306e\u8d70\u67fb\u578b\u96fb\u5b50\u9855\u5fae\u93e1\u50cf\uff08\u4e7e\u71e5\u72b6\u614b\uff09\u3001 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16px;\">\u00a0<br>\u3000\u30b2\u30ce\u30e0\u7de8\u96c6\u30c4\u30fc\u30eb\u3068\u3057\u3066\u9700\u8981\u306e\u9ad8\u3044CRISPR\/Cas9\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\uff08RNP\uff09\u304c\u7d50\u5408\u3059\u308b\u306e\u306b\u5fc5\u8981\u306aDNA\u914d\u5217\u304c\u7d44\u307f\u8fbc\u307e\u308c\u305f\u7d50\u6676\u3092\u4f5c\u88fd\u3057\u3001DNA\u7d50\u5408\u80fd\u3092\u5229\u7528\u3057\u305fRNP\u5c01\u5165\u306b\u3082\u6210\u529f\u3057\u307e\u3057\u305f\uff08\u56f33a\uff09\u3002DNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u306fDNA\u306a\u3069\u306e\u30bd\u30d5\u30c8\u30de\u30c6\u30ea\u30a2\u30eb\u306e\u307f\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u6750\u6599\u306b\u6bd4\u3079\u3066\u3001\u525b\u6027\u3084\u6a5f\u68b0\u7684\u5f37\u5ea6\u306e\u5411\u4e0a\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u5b9f\u969b\u306b\u3001\u4e7e\u71e5\u3001\u771f\u7a7a\u72b6\u614b\u30673\u6b21\u5143\u69cb\u9020\u3092\u4fdd\u3063\u305fRNP\u5c01\u5165\u7d50\u6676\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\uff08\u56f33b\uff09\u3002<br>\u3000\u305d\u3053\u3067\u3001\u3053\u306eRNP\u62c5\u6301\u7d50\u6676\u3092\u690d\u7269\u3078\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5c0e\u5165\u6280\u8853\u3067\u3042\u308b\u30d1\u30fc\u30c6\u30a3\u30af\u30eb\u30ac\u30f3\u6cd5\u306e\u30ad\u30e3\u30ea\u30a2\u3068\u3057\u3066\u5fdc\u7528\u3059\u308b\u3053\u3068\u3092\u8a66\u307f\u307e\u3057\u305f\u3002\u30d1\u30fc\u30c6\u30a3\u30af\u30eb\u30ac\u30f3\u6cd5\u306f\u30011\u339b\u7a0b\u5ea6\u306e\u91d1\u7c92\u5b50\u8868\u9762\u306b\u5c0e\u5165\u3057\u305f\u3044\u751f\u4f53\u5206\u5b50\u3092\u5438\u7740\u3055\u305b\u3001\u30ac\u30b9\u306e\u5727\u529b\u3067\u7269\u7406\u7684\u306b\u7d30\u80de\u5185\u306b\u6253\u3061\u8fbc\u3080\u65b9\u6cd5\u3067\u3059\u3002\u56fa\u3044\u7d30\u80de\u58c1\u3092\u6301\u3064\u690d\u7269\u7d30\u80de\u306b\u3082\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5c0e\u5165\u304c\u53ef\u80fd\u3067\u3059\u304c\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5438\u7740\u3067\u304d\u308b\u7bc4\u56f2\u306f\u91d1\u7c92\u5b50\u306e\u8868\u9762\u306e\u307f\u3067\u3042\u308b\u305f\u3081\u3001\u91d1\u7c92\u5b50\u5f53\u305f\u308a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5c0e\u5165\u91cf\u306b\u306f\u5236\u9650\u304c\u3042\u308a\u307e\u3059\u3002\u7d50\u6676\u5185\u90e8\u306b\u3082\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u5b50\u3092\u5c01\u5165\u3067\u304d\u308bDNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u306f\u9ad8\u52b9\u7387\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u5c0e\u5165\u3092\u5b9f\u73fe\u3059\u308b\u30ad\u30e3\u30ea\u30a2\u3068\u306a\u308b\u53ef\u80fd\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u56f33c\u306b\u7d50\u6676\u3068\u91d1\u7c92\u5b50\u3092\u7528\u3044\u305f\u30d1\u30fc\u30c6\u30a3\u30af\u30eb\u30ac\u30f3\u6cd5\u306e\u6982\u7565\u56f3\u3092\u793a\u3057\u307e\u3059\u3002RNP\u306f\u30b2\u30ce\u30e0\u306e\u6a19\u7684\u90e8\u4f4d\u3092\u5207\u65ad\u3057\u3001\u5909\u7570\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u3059\u3002RNP\u5c01\u5165\u5f8c\u3001\u7d50\u6676\u3092\u690d\u7269\u7d30\u80de\u306b\u6253\u3061\u8fbc\u3080\u3068\u3001\u78ba\u304b\u306b\u30b2\u30ce\u30e0\u306b\u5909\u7570\u304c\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3067\u304d\u307e\u3057\u305f\uff08\u56f33d\u3001e\uff09\u3002\u3053\u308c\u306f\u3001DNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u3092\u30d1\u30fc\u30c6\u30a3\u30af\u30eb\u30ac\u30f3\u6cd5\u306b\u5229\u7528\u3057\u305f\u521d\u3081\u3066\u306e\u4e8b\u4f8b\u3068\u306a\u308a\u307e\u3059\u3002<\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<p><span style=\"font-size: 16px;\"><strong>[\u6210\u679c\u306e\u610f\u7fa9]<br><\/strong><\/span><\/p>\r\n<hr \/>\r\n<p><span style=\"font-size: 16px;\">\u00a0<br>\u3000\u672c\u7814\u7a76\u306f\u3001\u7d50\u6676\u306b\u5206\u5b50\u3092\u6dfb\u52a0\u3059\u308b\u3068\u3044\u3046\u7c21\u4fbf\u304b\u3064\u7a4f\u3084\u304b\u306a\u6761\u4ef6\u4e0b\u3067\u5c01\u5165\u304c\u5b9f\u73fe\u3059\u308b\u305f\u3081\u3001\u74b0\u5883\u6761\u4ef6\u306b\u654f\u611f\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u5b50\u306e\u4fdd\u8b77\u3001\u8caf\u8535\u3001\u305d\u3057\u3066\u7d30\u80de\u3078\u306e\u8f38\u9001\u306b\u3068\u3063\u3066\u597d\u307e\u3057\u3044\u65b9\u6cd5\u3067\u3059\u3002\u539f\u7406\u7684\u306b\u69d8\u3005\u306a\u7a2e\u985e\u306e\u30ca\u30ce\u30b5\u30a4\u30ba\u306e\u5206\u5b50\u306e\u5c01\u5165\u3084\u91d1\u30ca\u30ce\u7c92\u5b50\u4ee5\u5916\u306e\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\u305f\u7d50\u6676\u4f5c\u88fd\u304c\u53ef\u80fd\u3067\u3042\u308a\u3001\u6c4e\u7528\u6027\u3082\u9ad8\u3044\u3067\u3059\u3002\u307e\u305f\u3001\u5149\u5b66\u7684\u30fb\u78c1\u6c17\u7684\u7279\u6027\u306a\u3069\u3092\u6709\u3059\u308b\u30ca\u30ce\u7c92\u5b50\u306f\u3001\u7c92\u5b50\u306e\u898f\u5247\u69cb\u9020\u5316\u306b\u3088\u308a\u305d\u306e\u7269\u6027\u306e\u5236\u5fa1\u6027\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u672c\u7814\u7a76\u306b\u3088\u308a\u5206\u5b50\u5c01\u5165\u5f8c\u3082\u7d50\u6676\u6027\u304c\u4fdd\u305f\u308c\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u690d\u7269\u80b2\u7a2e\u306e\u91cd\u8981\u306a\u7814\u7a76\u30c4\u30fc\u30eb\u3067\u3042\u308b\u30d1\u30fc\u30c6\u30a3\u30af\u30eb\u30ac\u30f3\u6cd5\u306b\u304a\u3051\u308b\u9ad8\u52b9\u7387\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u5b50\u5c0e\u5165\u306e\u305f\u3081\u306e\u65b0\u898f\u30ad\u30e3\u30ea\u30a2\u3084\u65b0\u898f\u6750\u6599\u5275\u88fd\u306a\u3069\u3078\u306e\u3055\u3089\u306a\u308b\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br><\/span><span style=\"font-size: 16px;\"><\/span><span style=\"font-size: 16px;\">\u00a0<br>\u3000\u672c\u7814\u7a76\u306f\u3001\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb\uff08JST\uff09\u7565\u7684\u5275\u9020\u7814\u7a76\u63a8\u9032\u4e8b\u696d CREST\u300c\u30b2\u30ce\u30e0\u30b9\u30b1\u30fc\u30eb\u306eDNA\u8a2d\u8a08\u30fb\u5408\u6210\u306b\u3088\u308b\u7d30\u80de\u5236\u5fa1\u6280\u8853\u306e\u5275\u51fa\u300d\uff08JPMJCR19S6)\u3001\u30bd\u30ed\u30d7\u30c1\u30df\u30b9\u30c8\u65e5\u672c\u8ca1\u56e3 \u5973\u6027\u7814\u7a76\u8005\u8cde\u3001CIRFE\u82e5\u624b\u6d3b\u6027\u5316\u652f\u63f4\u4e8b\u696d\u306e\u652f\u63f4\u306e\u3082\u3068\u3067\u884c\u308f\u308c\u305f\u3082\u306e\u3067\u3059\u3002X\u7dda\u5c0f\u89d2\u6563\u4e71\u6e2c\u5b9a\u306f\u3001SPring-8\uff08BL40B2\uff09\u306b\u304a\u3044\u3066\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/span><span style=\"font-size: 16px;\"><\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<p><span style=\"font-size: 16px;\"><strong>[\u7528\u8a9e\u89e3\u8aac]<br><\/strong><\/span><\/p>\r\n<hr \/>\r\n<p><span style=\"font-size: 16px;\">\u00a0<br><strong><span style=\"color: #800000;\">\u6ce81\uff09<\/span><\/strong>\u30d3\u30aa\u30c1\u30f3\uff1a<br>\u3000\u30d3\u30aa\u30c1\u30f3\u306f\u4f4e\u5206\u5b50\u30d3\u30bf\u30df\u30f3\u306e\u4e00\u7a2e\u3067\u3042\u308a\u3001\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5bfe\u3057\u3066\u5f37\u3044\u89aa\u548c\u6027\u3092\u6709\u3057\u3001\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff08\u30d3\u30aa\u30c1\u30f3\u2015\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3\u76f8\u4e92\u4f5c\u7528\uff09\u3002<br><\/span><\/p>\r\n<p><span style=\"font-size: 16px;\"><span style=\"color: #800000;\"><strong>\u6ce82\uff09<\/strong><\/span>\u30ad\u30e3\u30ea\u30a2\uff1a <br>\u3000\u6a19\u7684\u5206\u5b50\u3092\u7d30\u80de\u306b\u904b\u3076\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\u30b7\u30b9\u30c6\u30e0\u306b\u304a\u3044\u3066\u3001\u5206\u5b50\u306e\u904b\u3073\u624b\u306e\u5f79\u5272\u3092\u679c\u305f\u3059\u7269\u8cea\u3002<\/span><\/p>\r\n<p><span style=\"font-size: 16px;\"><strong><span style=\"color: #800000;\">\u6ce83\uff09<\/span><\/strong>CRISPR\/Cas9\uff1a<br>\u3000\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u3067\u3042\u308bCas9\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u4e8c\u6b21\u69cb\u9020\u3092\u3068\u308bgRNA(\u30ac\u30a4\u30c9RNA)\u306e\u8907\u5408\u4f53\u306b\u3088\u3063\u3066\u3001RNA\u304c\u6307\u5b9a\u3057\u305f\u914d\u5217\u3092\u3082\u3064DNA\u3092\u5207\u65ad\u3059\u308b\u6280\u8853\u3002\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306e\u4e2d\u3067\u6700\u3082\u666e\u53ca\u3057\u305f\u65b9\u6cd5\u3067\u3001\u751f\u7269\u306e\u80b2\u7a2e\u3078\u306e\u6d3b\u7528\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002<br><\/span><\/p>\r\n<p><span style=\"font-size: 16px;\"><strong><span style=\"color: #800000;\">\u6ce84\uff09<\/span><\/strong>\u5c40\u5728\u8868\u9762\u30d7\u30e9\u30ba\u30e2\u30f3\u5171\u9cf4\uff1a<br>\u3000\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb\u306b\u307e\u3067\u5fae\u7c92\u5b50\u5316\u3057\u305f\u91d1\u5c5e\u306b\u5149\u304c\u7167\u5c04\u3055\u308c\u305f\u969b\u306b\u3001\u96fb\u5b50\u306e\u96c6\u56e3\u904b\u52d5\u306b\u3088\u308b\u632f\u52d5\uff08\u30d7\u30e9\u30ba\u30e2\u30f3\uff09\u304c\u305d\u306e\u8868\u9762\u306b\u5c40\u5728\u5316\u3059\u308b\u3053\u3068\u3002\u3053\u306e\u5c40\u5728\u5316\u3057\u305f\u30d7\u30e9\u30ba\u30e2\u30f3\u304c\u5b58\u5728\u3059\u308b\u8fd1\u508d\u9818\u57df\u3067\u306f\u3001\u5f37\u3044\u5897\u5f37\u96fb\u5834\u304c\u767a\u751f\u3057\u7269\u8cea\u3092\u52b1\u8d77\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308b\u305f\u3081\u3001\u767a\u5149\u5897\u5f37\u306a\u3069\u304c\u671f\u5f85\u3067\u304d\u308b\u3002<br><\/span><\/p>\r\n<p><span style=\"font-size: 16px;\"><strong><span style=\"color: #800000;\">\u6ce85\uff09<\/span><\/strong>\u7c92\u5b50\u5145\u586b\u7387\uff1a<br>\u3000\u7d50\u6676\u5185\u90e8\u306b\u304a\u3044\u3066\u3001\u7a7a\u9593\u3092\u5360\u6709\u3059\u308b\u7c92\u5b50\u306e\u5272\u5408\u3002\u7c92\u5b50\u5145\u586b\u7387\u304c\u4f4e\u3044\u307b\u3069\u300c\u30b9\u30ab\u30b9\u30ab\u300d\u306e\u7d50\u6676\u3068\u306a\u308b\u3002<\/span><\/p>\r\n<p><span style=\"font-size: 16px;\"><strong><span style=\"color: #800000;\">\u6ce86\uff09<\/span><\/strong>\u5171\u7126\u70b9\u30ec\u30fc\u30b6\u30fc\u9855\u5fae\u93e1\uff1a<br>\u3000\u6750\u6599\u306e\u5185\u90e8\u69cb\u9020\u3092\u4e09\u6b21\u5143\u7684\u306b\u89b3\u5bdf\u3059\u308b\u88c5\u7f6e\u3002\u7126\u70b9\u9762\u4f4d\u7f6e\u4ee5\u5916\u306e\u5149\u3092\u30ab\u30c3\u30c8\u3059\u308b\u3053\u3068\u3067\u3001\u5149\u5b66\u7684\u65ad\u5c64\u50cf\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/span><span style=\"font-size: 16px;\"><\/span><\/p>\r\n<p><span style=\"font-size: 16px;\"><strong><span style=\"color: #800000;\">\u6ce87\uff09<\/span><\/strong>X\u7dda\u5c0f\u89d2\u6563\u4e71\uff1a<br>\u3000\u7269\u8cea\u306bX\u7dda\u3092\u7167\u5c04\u3057\u3001\u305d\u306e\u6563\u4e71\u5f37\u5ea6\u30d1\u30bf\u30fc\u30f3\u304b\u3089\u7269\u8cea\u306e\u5468\u671f\u7684\u306a\u69cb\u9020\u60c5\u5831\u3092\u5f97\u308b\u624b\u6cd5\u3002<\/span><span style=\"font-size: 16px;\"><\/span><\/p>\r\n<p><span style=\"font-size: 16px;\"><strong><span style=\"color: #800000;\">\u6ce88\uff09<\/span><\/strong>\u8d70\u67fb\u578b\u96fb\u5b50\u9855\u5fae\u93e1\uff1a<br>\u3000\u96fb\u5b50\u7dda\u3092\u7167\u5c04\u3057\u3066\u8a66\u6599\u304b\u3089\u653e\u51fa\u3055\u308c\u305f\u96fb\u5b50\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u3067\u3001\u30ca\u30ce\uff5e\u30de\u30a4\u30af\u30ed\u30e1\u30fc\u30c8\u30eb\u30b5\u30a4\u30ba\u306e\u5f62\u72b6\u3084\u8868\u9762\u306e\u5fae\u7d30\u69cb\u9020\u3092\u89b3\u5bdf\u3059\u308b\u88c5\u7f6e\u3002<\/span><span style=\"font-size: 16px;\"><\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<p><span style=\"font-size: 16px;\"><strong>[\u8ad6\u6587\u60c5\u5831]<br><\/strong><\/span><\/p>\r\n<hr \/>\r\n<p><span style=\"font-size: 16px;\">\u00a0<br>\u96d1\u8a8c\u540d\uff1aSoft Matter<\/span><br><span style=\"font-size: 16px;\"><span style=\"font-size: 16px;\">\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1aDNA-functionalized colloidal crystals for macromolecular encapsulation<\/span><br><span style=\"font-size: 16px;\">\u8457\u8005\uff1a<span style=\"text-decoration: underline;\">Maasa Yokomori<\/span>, Hayato Suzuki, Akiyoshi Nakamura, Shigeo S. Sugano and <span style=\"text-decoration: underline;\">Miho Tagawa<\/span>\u3000\u203b\u672c\u5b66\u95a2\u4fc2\u6559\u54e1\u306f\u4e0b\u7dda<\/span><br><span style=\"font-size: 16px;\">DOI\uff1a10.1039\/D2SM00949H\u00a0<\/span><br><span style=\"font-size: 16px;\">URL\uff1a<a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2022\/SM\/D2SM00949H\">https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2022\/SM\/D2SM00949H<\/a><\/span><\/span><\/p>\r\n<p><br><br><strong><span style=\"font-size: 16px;\">\u672a\u6765\u6750\u6599\u30fb\u30b7\u30b9\u30c6\u30e0\u7814\u7a76\u6240\u3000\u5b87\u6cbb\u539f\u7814\u7a76\u5ba4<\/span><\/strong><br><a href=\"https:\/\/ujihara.material.nagoya-u.ac.jp\/\">https:\/\/ujihara.material.nagoya-u.ac.jp\/<\/a><\/p>\r\n<p><br>\u25c6<a href=\"https:\/\/www.nagoya-u.ac.jp\/researchinfo\/result\/2022\/09\/dna.html\" target=\"_blank\" rel=\"noopener\">\u540d\u53e4\u5c4b\u5927\u5b66 \u60c5\u5831\u30b5\u30a4\u30c8\u306f\u3053\u3061\u3089\uff1e\uff1e\uff1e<\/a><br><br>\u25c6<a href=\"https:\/\/www.nagoya-u.ac.jp\/researchinfo\/result\/upload\/20220907_imass.pdf\">\u540d\u53e4\u5c4b\u5927\u5b66\u306e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\uff08\u672c\u6587\uff09\u306f\u3053\u3061\u3089\uff1e\uff1e\uff1e<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u3010\u672c\u7814\u7a76\u306e\u30dd\u30a4\u30f3\u30c8\u3011 DNA\u3092\u4ecb\u3057\u3066\u7c92\u5b50\u9593\u8ddd\u96e2\u3092\u5236\u5fa1\u3057\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u9175\u7d20\u306a\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u5b50\u3092\u5c01\u5165\u53ef\u80fd\u306aDNA\u4fee\u98fe\u91d1\u30ca\u30ce\u7c92\u5b50\u7d50\u6676\u306e\u4f5c\u88fd\u306b\u6210\u529f\u3057\u305f\u3002 \u7d50\u6676\u306b\u30d3\u30aa\u30c1\u30f3\u6ce81\uff09\u5206\u5b50\u3084\u9175\u7d20\u304c\u7d50\u5408\u3059\u308b\u305f\u3081\u306eDNA\u3092\u7d44\u307f\u8fbc\u3080\u3053\u3068\u3067\u3001\u7c21\u4fbf [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":5482,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-5483","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"acf":[],"aioseo_notices":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-07 06:58:14","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.imass.nagoya-u.ac.jp\/en\/wp-json\/wp\/v2\/posts\/5483","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.imass.nagoya-u.ac.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.imass.nagoya-u.ac.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.imass.nagoya-u.ac.jp\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.imass.nagoya-u.ac.jp\/en\/wp-json\/wp\/v2\/comments?post=5483"}],"version-history":[{"count":75,"href":"https:\/\/www.imass.nagoya-u.ac.jp\/en\/wp-json\/wp\/v2\/posts\/5483\/revisions"}],"predecessor-version":[{"id":5573,"href":"https:\/\/www.imass.nagoya-u.ac.jp\/en\/wp-json\/wp\/v2\/posts\/5483\/revisions\/5573"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.imass.nagoya-u.ac.jp\/en\/wp-json\/wp\/v2\/media\/5482"}],"wp:attachment":[{"href":"https:\/\/www.imass.nagoya-u.ac.jp\/en\/wp-json\/wp\/v2\/media?parent=5483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.imass.nagoya-u.ac.jp\/en\/wp-json\/wp\/v2\/categories?post=5483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.imass.nagoya-u.ac.jp\/en\/wp-json\/wp\/v2\/tags?post=5483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}